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The Role of Genetics and Family History in Melanoma Risk

posted: Aug. 21, 2024.

Melanoma is an aggressive type of skin cancer. Genetics and family history play significant roles in the development of melanoma. Your dermatologist can tell you more. Dr. Richard Cirelli at Sunwest Dermatology and Skin Cancer Treatment Center provides a wide range of dermatology treatments and services, including diagnosis and treatment of melanoma. He has two convenient locations in Prescott and Prescott Valley, AZ.

What You Need to Know About Genetics and Melanoma

Did you know 5% to 10% of all melanomas are inherited? Your genes play an essential role in your risk of developing melanoma. If someone in your family has developed melanoma, you may be at greater risk of developing melanoma.

Other types of skin cancer may also have a genetic component. Consider these genetic syndromes associated with increased skin cancer risk:

  • Basal cell nevus syndrome can increase the risk of developing basal cell carcinoma
  • Oculocutaneous albinism, epidermolysis bullosa, and Fanconi anemia can increase the risk of developing squamous cell carcinoma
  • The presence of the germline tumor suppressor gene can increase the risk of developing melanoma
  • Xeroderma pigmentosum can increase the risk of developing all types of skin cancer

Research has been conducted on the use of various preventive substances to reduce risk in individuals with a genetic risk for skin cancer. Studies of isotretinoin and acitretin have demonstrated a reduction in skin cancer tumors per year.

Treatment of melanoma can include:

  • Mohs surgery to remove cancerous tissue layer by layer
  • Surgical excision to remove cancerous tissue
  • Radiation therapy to kill cancerous cells
  • Chemotherapy, if the cancer has spread

Melanoma prevention is essential for everyone, and it is even more critical if you have a genetic risk of developing melanoma. You need to:

  • Limit your time out in direct sunlight
  • Wear a sunscreen with an SPF of at least 50
  • Stay out of the sun between the hours of 10 AM to 2 PM, when ultraviolet rays are most damaging
  • Wear a hat, sunglasses, and other protective clothing when you are outside

Want to Know More About Genetics and Melanoma Risk?

Call Dr. Richard Cirelli at Sunwest Dermatology and Skin Cancer Treatment Center to discover more about the role genetics plays in melanoma risk and melanoma treatment options. You can reach him in Prescott or Prescott Valley, AZ, by calling (928) 445-7546, so call today.

Tags: Melanoma
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